AustralieFrV1, Main, Exploration, bibRecord, 001582

The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood

Identifieur interne : 001582 ( Main/Exploration ); précédent : 001581; suivant : 001583

The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood

Auteurs : T. Mansell [Australie] ; B. Novakovic [Australie] ; B. Meyer [Australie] ; P. Rzehak [Australie, Allemagne] ; P. Vuillermin [Australie] ; A-L Ponsonby [Australie] ; F. Collier [Australie] ; D. Burgner [Australie] ; R. Saffery [Australie] ; J. Ryan [Australie, France]

Source :

Translational Psychiatry [ 2158-3188 ] ; 2016.

RBID : PMC:4872456

Descripteurs français

English descriptors

KwdEn :
- Adult, Anxiety (genetics), Anxiety (metabolism), Cohort Studies, DNA Methylation, Depression (genetics), Depression (metabolism), Female, Fetal Blood (metabolism), Humans, Infant, Newborn, Insulin-Like Growth Factor II (genetics), Insulin-Like Growth Factor II (metabolism), Linear Models, Male, Pregnancy, Pregnancy Complications (genetics), Pregnancy Complications (metabolism), Prospective Studies, RNA, Long Noncoding (metabolism), Stress, Psychological (genetics), Stress, Psychological (metabolism).
MESH :
- chemical , genetics : Insulin-Like Growth Factor II.
- genetics : Anxiety, Depression, Pregnancy Complications, Stress, Psychological.
- metabolism : Anxiety, Depression, Fetal Blood, Insulin-Like Growth Factor II, Pregnancy Complications, RNA, Long Noncoding, Stress, Psychological.
- Adult, Cohort Studies, DNA Methylation, Female, Humans, Infant, Newborn, Linear Models, Male, Pregnancy, Prospective Studies.

Abstract

Compelling evidence suggests that maternal mental health in pregnancy can influence fetal development. The imprinted genes, insulin-like growth factor 2 (IGF2) and H19, are involved in fetal growth and each is regulated by DNA methylation. This study aimed to determine the association between maternal mental well-being during pregnancy and differentially methylated regions (DMRs) of IGF2 (DMR0) and the IGF2/H19 imprinting control region (ICR) in newborn offspring. Maternal depression, anxiety and perceived stress were assessed at 28 weeks of pregnancy in the Barwon Infant Study (n=576). DNA methylation was measured in purified cord blood mononuclear cells using the Sequenom MassArray Platform. Maternal anxiety was associated with a decrease in average ICR methylation (Δ=−2.23% 95% CI=−3.68 to −0.77%), and across all six of the individual CpG units in anxious compared with non-anxious groups. Birth weight and sex modified the association between prenatal anxiety and infant methylation. When stratified into lower (⩽3530 g) and higher (>3530 g) birth weight groups using the median birth weight, there was a stronger association between anxiety and ICR methylation in the lower birth weight group (Δ=−3.89% 95% CI=−6.06 to −1.72%), with no association in the higher birth weight group. When stratified by infant sex, there was a stronger association in female infants (Δ=−3.70% 95% CI=−5.90 to −1.51%) and no association in males. All the linear regression models were adjusted for maternal age, smoking and folate intake. These findings show that maternal anxiety in pregnancy is associated with decreased IGF2/H19 ICR DNA methylation in progeny at birth, particularly in female, low birth weight neonates. ICR methylation may help link poor maternal mental health and adverse birth outcomes, but further investigation is needed.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872456

DOI: 10.1038/tp.2016.32
PubMed: 27023171
PubMed Central: 4872456

Affiliations:

Allemagne, Australie, France

Le document en format XML

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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The effects of maternal anxiety during pregnancy on <italic>IGF2</italic>
/<italic>H19</italic>
 methylation in cord blood</title>
<author><name sortKey="Mansell, T" sort="Mansell, T" uniqKey="Mansell T" first="T" last="Mansell">T. Mansell</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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, Parkville, VIC,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Saffery, R" sort="Saffery, R" uniqKey="Saffery R" first="R" last="Saffery">R. Saffery</name>
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, Parkville, VIC,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Paediatrics, The University of Melbourne</institution>
, Parkville, VIC,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ryan, J" sort="Ryan, J" uniqKey="Ryan J" first="J" last="Ryan">J. Ryan</name>
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, Parkville, VIC,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Paediatrics, The University of Melbourne</institution>
, Parkville, VIC,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Inserm U1061, Hopital La Colombiere, Universite Montpellier</institution>
, Montpellier,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Epidemiology and Preventative Medicine, School of Public Health and Preventative Medicine, Monash University</institution>
, Prahran, VIC,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Translational Psychiatry</title>
<idno type="eISSN">2158-3188</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Anxiety (genetics)</term>
<term>Anxiety (metabolism)</term>
<term>Cohort Studies</term>
<term>DNA Methylation</term>
<term>Depression (genetics)</term>
<term>Depression (metabolism)</term>
<term>Female</term>
<term>Fetal Blood (metabolism)</term>
<term>Humans</term>
<term>Infant, Newborn</term>
<term>Insulin-Like Growth Factor II (genetics)</term>
<term>Insulin-Like Growth Factor II (metabolism)</term>
<term>Linear Models</term>
<term>Male</term>
<term>Pregnancy</term>
<term>Pregnancy Complications (genetics)</term>
<term>Pregnancy Complications (metabolism)</term>
<term>Prospective Studies</term>
<term>RNA, Long Noncoding (metabolism)</term>
<term>Stress, Psychological (genetics)</term>
<term>Stress, Psychological (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN long non codant (métabolisme)</term>
<term>Adulte</term>
<term>Anxiété (génétique)</term>
<term>Anxiété (métabolisme)</term>
<term>Complications de la grossesse (génétique)</term>
<term>Complications de la grossesse (métabolisme)</term>
<term>Dépression (génétique)</term>
<term>Dépression (métabolisme)</term>
<term>Facteur de croissance IGF-II (génétique)</term>
<term>Facteur de croissance IGF-II (métabolisme)</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Modèles linéaires</term>
<term>Mâle</term>
<term>Méthylation de l'ADN</term>
<term>Nouveau-né</term>
<term>Sang foetal (métabolisme)</term>
<term>Stress psychologique (génétique)</term>
<term>Stress psychologique (métabolisme)</term>
<term>Études de cohortes</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Insulin-Like Growth Factor II</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Anxiety</term>
<term>Depression</term>
<term>Pregnancy Complications</term>
<term>Stress, Psychological</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Anxiété</term>
<term>Complications de la grossesse</term>
<term>Dépression</term>
<term>Facteur de croissance IGF-II</term>
<term>Stress psychologique</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Anxiety</term>
<term>Depression</term>
<term>Fetal Blood</term>
<term>Insulin-Like Growth Factor II</term>
<term>Pregnancy Complications</term>
<term>RNA, Long Noncoding</term>
<term>Stress, Psychological</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN long non codant</term>
<term>Anxiété</term>
<term>Complications de la grossesse</term>
<term>Dépression</term>
<term>Facteur de croissance IGF-II</term>
<term>Sang foetal</term>
<term>Stress psychologique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Cohort Studies</term>
<term>DNA Methylation</term>
<term>Female</term>
<term>Humans</term>
<term>Infant, Newborn</term>
<term>Linear Models</term>
<term>Male</term>
<term>Pregnancy</term>
<term>Prospective Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Modèles linéaires</term>
<term>Mâle</term>
<term>Méthylation de l'ADN</term>
<term>Nouveau-né</term>
<term>Études de cohortes</term>
<term>Études prospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Compelling evidence suggests that maternal mental health in pregnancy can influence fetal development. The imprinted genes, insulin-like growth factor 2 (<italic>IGF2</italic>
) and <italic>H19,</italic>
 are involved in fetal growth and each is regulated by DNA methylation. This study aimed to determine the association between maternal mental well-being during pregnancy and differentially methylated regions (DMRs) of <italic>IGF2</italic>
 (DMR0) and the <italic>IGF2/H19</italic>
 imprinting control region (ICR) in newborn offspring. Maternal depression, anxiety and perceived stress were assessed at 28 weeks of pregnancy in the Barwon Infant Study (<italic>n</italic>
=576). DNA methylation was measured in purified cord blood mononuclear cells using the Sequenom MassArray Platform. Maternal anxiety was associated with a decrease in average ICR methylation (Δ=−2.23% 95% CI=−3.68 to −0.77%), and across all six of the individual CpG units in anxious compared with non-anxious groups. Birth weight and sex modified the association between prenatal anxiety and infant methylation. When stratified into lower (⩽3530 g) and higher (>3530 g) birth weight groups using the median birth weight, there was a stronger association between anxiety and ICR methylation in the lower birth weight group (Δ=−3.89% 95% CI=−6.06 to −1.72%), with no association in the higher birth weight group. When stratified by infant sex, there was a stronger association in female infants (Δ=−3.70% 95% CI=−5.90 to −1.51%) and no association in males. All the linear regression models were adjusted for maternal age, smoking and folate intake. These findings show that maternal anxiety in pregnancy is associated with decreased <italic>IGF2</italic>
/<italic>H19</italic>
 ICR DNA methylation in progeny at birth, particularly in female, low birth weight neonates. ICR methylation may help link poor maternal mental health and adverse birth outcomes, but further investigation is needed.</p>
</div>
</front>
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</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
</country>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Mansell, T" sort="Mansell, T" uniqKey="Mansell T" first="T" last="Mansell">T. Mansell</name>
</noRegion>
<name sortKey="Burgner, D" sort="Burgner, D" uniqKey="Burgner D" first="D" last="Burgner">D. Burgner</name>
<name sortKey="Burgner, D" sort="Burgner, D" uniqKey="Burgner D" first="D" last="Burgner">D. Burgner</name>
<name sortKey="Collier, F" sort="Collier, F" uniqKey="Collier F" first="F" last="Collier">F. Collier</name>
<name sortKey="Collier, F" sort="Collier, F" uniqKey="Collier F" first="F" last="Collier">F. Collier</name>
<name sortKey="Mansell, T" sort="Mansell, T" uniqKey="Mansell T" first="T" last="Mansell">T. Mansell</name>
<name sortKey="Meyer, B" sort="Meyer, B" uniqKey="Meyer B" first="B" last="Meyer">B. Meyer</name>
<name sortKey="Meyer, B" sort="Meyer, B" uniqKey="Meyer B" first="B" last="Meyer">B. Meyer</name>
<name sortKey="Novakovic, B" sort="Novakovic, B" uniqKey="Novakovic B" first="B" last="Novakovic">B. Novakovic</name>
<name sortKey="Novakovic, B" sort="Novakovic, B" uniqKey="Novakovic B" first="B" last="Novakovic">B. Novakovic</name>
<name sortKey="Ponsonby, A L" sort="Ponsonby, A L" uniqKey="Ponsonby A" first="A-L" last="Ponsonby">A-L Ponsonby</name>
<name sortKey="Ponsonby, A L" sort="Ponsonby, A L" uniqKey="Ponsonby A" first="A-L" last="Ponsonby">A-L Ponsonby</name>
<name sortKey="Ryan, J" sort="Ryan, J" uniqKey="Ryan J" first="J" last="Ryan">J. Ryan</name>
<name sortKey="Ryan, J" sort="Ryan, J" uniqKey="Ryan J" first="J" last="Ryan">J. Ryan</name>
<name sortKey="Ryan, J" sort="Ryan, J" uniqKey="Ryan J" first="J" last="Ryan">J. Ryan</name>
<name sortKey="Rzehak, P" sort="Rzehak, P" uniqKey="Rzehak P" first="P" last="Rzehak">P. Rzehak</name>
<name sortKey="Saffery, R" sort="Saffery, R" uniqKey="Saffery R" first="R" last="Saffery">R. Saffery</name>
<name sortKey="Saffery, R" sort="Saffery, R" uniqKey="Saffery R" first="R" last="Saffery">R. Saffery</name>
<name sortKey="Vuillermin, P" sort="Vuillermin, P" uniqKey="Vuillermin P" first="P" last="Vuillermin">P. Vuillermin</name>
<name sortKey="Vuillermin, P" sort="Vuillermin, P" uniqKey="Vuillermin P" first="P" last="Vuillermin">P. Vuillermin</name>
<name sortKey="Vuillermin, P" sort="Vuillermin, P" uniqKey="Vuillermin P" first="P" last="Vuillermin">P. Vuillermin</name>
<name sortKey="Vuillermin, P" sort="Vuillermin, P" uniqKey="Vuillermin P" first="P" last="Vuillermin">P. Vuillermin</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Rzehak, P" sort="Rzehak, P" uniqKey="Rzehak P" first="P" last="Rzehak">P. Rzehak</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Ryan, J" sort="Ryan, J" uniqKey="Ryan J" first="J" last="Ryan">J. Ryan</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood

The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood

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